๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

HSV infection and immunosuppression

โœ Scribed by Rakesh Sindhi

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
45 KB
Volume
12
Category
Article
ISSN
1527-6465

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โœฆ Synopsis

In their brief report, Campsen et al. 1 remind us of the potential severity of necrotizing HSV hepatitis, which complicated live donor, right lobe liver transplant in a 57-year old Hepatitis C recipient. Terminal findings also included resistant pseudomonas intra-abdominal sepsis due to a partial bile duct disruption. A prominent theme of this report is that herpes virus prophylaxis could have been considered if donor HSV serologic status was known pre-transplant. Such an inference is logical given that in contemporary liver transplantation immunosuppressive protocols, antiviral prophylaxis is often predicated on mismatches between donor and recipient serologic status for cytomegalovirus and EBV, but not HSV.

However, before such an inference becomes the impetus to change protocol, one must acknowledge the unique predisposition to infectious morbidity present in their particular patient, and therapeutic measures that might have been initiated as first-line responses:

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