Proliferative activity and in vitro repl
β
Allah Detta; June Harland; Isma Hanif; S. Moira Brown; Garth Cruickshank
π
Article
π
2003
π
John Wiley and Sons
π
English
β 315 KB
## Abstract ## Background The neurotropic herpes simplex virus mutant HSV1716 lacks the gene encoding the virulence factor ICP34.5 and cannot replicate in nonβdividing cells where proliferating cell nuclear antigen (PCNA) is not actively engaged in cellular DNA synthesis. In the brain, tumoral exp