𝔖 Bobbio Scriptorium
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HSV 1716 shows activity in metastatic melanoma


Book ID
120866920
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2001
Weight
154 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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## Abstract ## Background The neurotropic herpes simplex virus mutant HSV1716 lacks the gene encoding the virulence factor ICP34.5 and cannot replicate in non‐dividing cells where proliferating cell nuclear antigen (PCNA) is not actively engaged in cellular DNA synthesis. In the brain, tumoral exp