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Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines

✍ Scribed by Megumi Senju; Naoko Sueoka; Akemi Sato; Kentaro Iwanaga; Yukinori Sakao; Shinji Tomimitsu; Masaki Tominaga; Koji Irie; Shinichiro Hayashi; Eisaburo Sueoka


Book ID
106123503
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
494 KB
Volume
132
Category
Article
ISSN
1432-1335

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Vitamin C transiently arrests cancer cel
✍ Christopher G. Thomas; Patra E. Vezyraki; Vicky P. Kalfakakou; Angelos M. Evange πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 489 KB πŸ‘ 2 views

Regulation of cell cycle progression involves redox (oxidation-reduction)-dependent modification of proteins including the mitosis-inducing phosphatase Cdc25C. The role of vitamin C (ascorbic acid, ASC), a known modulator of the cellular redox status, in regulating mitotic entry was investigated in