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Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells

✍ Scribed by Xiaokui Yang; Jiandong Wang; Ying Zhou; Yamei Wang; Shuyu Wang; Weiyuan Zhang


Book ID
116335859
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
692 KB
Volume
321
Category
Article
ISSN
0304-3835

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## Abstract Current approaches to the treatment of ovarian cancer are limited because of the development of resistance to chemotherapy. Prohibitin (Phb1) is a possible candidate protein that contributes to development of drug resistance, which could be targeted in neoplastic cells. Phb1 is a highly