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HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma

✍ Scribed by Ramadevi Nimmanapalli; Elvira Gerbino; William S. Dalton; Varsha Gandhi; Melissa Alsina

Book ID
108675829
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
486 KB
Volume
142
Category
Article
ISSN
0007-1048

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The bone marrow micro-environment produces a number of different survival factors that are important for the malignant growth and drug resistance of multiple myeloma (MM) cells. One of the main factors reported to be essential for survival and growth of MM cells in some experimental systems is IL-6.