Hsp70 chaperones: Cellular functions and molecular mechanism
โ Scribed by M. P. Mayer; B. Bukau
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 398 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1420-682X
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The heat shock proteins (HSP) gp96 and hsp70 have been shown to have a critical role in eliciting adaptive immune responses to cancers and viruses. This role derives from (i) their ability to chaperone antigenic peptides generated in the cells from which the HSP are isolated, and (ii) their capacity
## Abstract The discovery of โmolecular chaperonesโ has dramatically changed our concept of cellular protein folding. Rather than folding spontaneously, most newly synthesized polypeptide chains seem to acquire their native conformation in a reaction mediated by these versatile helper proteins. Und