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HRGC assay of antihistaminic drugs in plasma samples using a nitrogen-phosphorus detector

✍ Scribed by Giachetti, C. ;Poletti, P. ;Zanolo, G.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
257 KB
Volume
11
Category
Article
ISSN
0935-6304

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✦ Synopsis

Thirteen antihistaminic drugs are separated on a CP-Sil 5 capillary column and are evaluated by a NP detector after extraction of spiked plasma samples, alkalinized, in a solvent mixture of chloroform, dichloromethane, and methanol. Intra-and inter-assay analyses showed high reliability, therefore this method can be usefully applied in experimental or clinical pharmacokinetic investigations.

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