HRAS1 and INS genes are relocated but not structurally altered as a result of the t(7;11) (p15;p15) in a clone from a patient with acute myeloid leukaemia (M4)

The chromosome translocation t(7;11)(p15

The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9

✍ Takeshi Taketani; Tomohiko Taki; Ryoichi Ono; Yukio Kobayashi; Kohmei Ida; Yasuh 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB

The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part