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HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase

✍ Scribed by Pim, David; Thomas, Miranda; Javier, Ron; Gardiol, Daniela; Banks, Lawrence


Book ID
110062721
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
450 KB
Volume
19
Category
Article
ISSN
0950-9232

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Human scribble (hScrib), which was identified as substrate of human papillomavirus (HPV) E6 for ubiquitin-mediated degradation dependent on ubiquitin-protein ligase E6AP, is a human homolog of Drosophila neoplastic tumor suppressor scribble, in which mutation causes loss of polarity and overgrowth o