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HPTLC assay of cephalexin and cefaclor in pharmaceuticals

✍ Scribed by D. Agbaba; S. Eric; D. Zivanov Stakic; S. Vladimirov

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
76 KB
Volume
12
Category
Article
ISSN
0269-3879

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✦ Synopsis

A simple and reliable HPTLC method for the simultaneous determination of cephalexin and cefaclor is developed and validated. The methanol-ethyl acetate-acetone-water (5:2.5:2.5:1.5 v/v/v/v) solvent system is used for the quantitative evaluation of chromatograms. The chromatographic zones, corresponding to the spots of cephalexin and cefaclor on the silica gel plates, are scanned in the reflectance/absorbance mode at 265 nm. The method is found to be reproducible and convenient for the quantitative analysis of cephalexin and cefaclor in its dosage forms.

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