Cathepsin K inhibitors prevent bone loss
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Brenda L Pennypacker; Le T Duong; Tara E Cusick; Patricia J Masarachia; Michael
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Article
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2011
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American Society for Bone and Mineral Research
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English
β 170 KB
## Abstract Two cathepsin K inhibitors (CatKIs) were compared with alendronate (ALN) for their effects on bone resorption and formation in ovariectomized (OVX) rabbits. The OVX model was validated by demonstrating significant loss (9.8% to 12.8%) in lumbar vertebral bone mineral density (LV BMD) in