𝔖 Bobbio Scriptorium
✦   LIBER   ✦

HPMA Copolymer–Doxorubicin–Gadolinium Conjugates: Synthesis, Characterization, and in vitro Evaluation

✍ Scribed by Bahar Zarabi; Anjan Nan; Jiachen Zhuo; Rao Gullapalli; Hamidreza Ghandehari

Book ID
102472944
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
362 KB
Volume
8
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

This study describes the synthesis, characterization, and in vitro evaluation of N‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer–gadolinium (Gd)–doxorubicin (Dox) conjugates. Copolymers of HPMA were derivatized to incorporate side chains for Gd chelation and Dox conjugation. The conjugates were characterized by their side chain contents, T~1~ relaxivity (r~1~), stability, and in vitro cytotoxicity. High stability and relaxivity of these conjugates coupled with low toxicity show their potential for monitoring the in vivo fate of HPMA‐based drug delivery systems by magnetic resonance imaging techniques.

magnified image

📜 SIMILAR VOLUMES

Synthesis and Biological Evaluation of D
Synthesis and Biological Evaluation of Disulfide-Linked HPMA Copolymer-Mesochlorin e6 Conjugates
✍ Vaikunth Cuchelkar; Pavla Kopečková; Jindřich Kopeček 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

## Abstract Novel polymeric delivery systems for the photosensitizer mesochlorin e~6~ (Mce~6~) were synthesized to overcome problems of systemic toxicity. A disulfide bond was included to allow for quick release of Mce~6~ from the __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer backbone once

HPMA copolymer–anticancer drug–OV-TL16 a
HPMA copolymer–anticancer drug–OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro
✍ Vladimir Omelyanenko; Christine Gentry; Pavla Kopečková; Jindřich Kopeček 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 243 KB

The binding, internalization, subcellular trafficking and in vitro cytotoxicity of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-anti-cancer drug-OV-TL16 antibody (Ab) conjugates in the ovarian carcinoma OVCAR-3 cell line have been investigated. Adriamycin (ADR) and meso chlorin e6 mono(N-2-ami