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HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Ovarian Carcinoma Cells by the Disruption of Mitochondrial Function

✍ Scribed by Malugin, Alexander; Kopečková, Pavla; Kopeček, Jindřich


Book ID
126842409
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
506 KB
Volume
3
Category
Article
ISSN
1543-8384

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Anticancer activity and main mechanisms of action of free doxorubicin (DOX) and HPMA copolymer-bound DOX (P(GFLG)-DOX) were studied in solid tumor mice models of DOX sensitive and resistant human ovarian carcinoma. Free DOX was effective only in sensitive tumors decreasing the tumor size about three