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HPLC separated fractions of 99mTc(NaBH4)-HEDP as myocardial infarct imaging agents

โœ Scribed by Debra L. Ferguson; Karen Libson; Julius P. Zodda; William R. Heineman; Edward Deutsch

Book ID
103919652
Publisher
Elsevier Science
Year
1986
Weight
372 KB
Volume
37
Category
Article
ISSN
0883-2889

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โœฆ Synopsis

Component fractions of 99mTc(NaBH4)-HEDP mixtures, isolated by anion exchange high performance liquid chromatography (HPLC), have been evaluated as myocardial infarct imaging agents in two animal models. Results from both the isoproterenol-induced myocardial infarction model, and the heat-induced myocardial necrosis model, show that the several HPLC isolated components exhibit significantly different abnormal/normal heart uptake ratios. In addition, the HPLC isolated component of shortest chromatographic retention time exhibits a higher abnormal/normal heart uptake ratio than does 99mTc(Sn)-PyP, the current agent of choice for clinical myocardial infarct imaging.

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The effect of formulation conditions on the distribution of 99mTc(NaBH4)-HEDP components separated by anion exchange HPLC
โœ Julius P. Zodda; Shinzo Tanabe; William R. Heineman; Edward Deutsch ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science โš– 763 KB

Reduction of 99mTcO4- by NaBH4 in the presence of HEDP leads to a mixture of 99mTc-containing complexes which can be separated by anion exchange high performance liquid chromatography (HPLC). The distribution of complexes within this mixture can be varied by controlling pH, the concentration of HEDP