HPLC analysis of indium-111 diethylenetriaminepentaacetic acid (111In-DTPA) radiopharmaceutical

✍ Scribed by Manhar M. Vora

• Book ID: 103922616
• Publisher: Elsevier Science
• Year: 1991
• Weight: 744 KB
• Volume: 42
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(91)90119-l

✦ Synopsis

Indium-I 1 I diethylenetriaminepentaacetic acid ("'In-DTPA) was analyzed by reversed-phase HPLC. On-line U.V. (220 mm) and radioactivity (NaI) detectors allowed simultaneous detection and quantitation of "'In-DTPA radiopharmaceutical and free DTPA. The optimum HPLC conditions were derived from systematic study of the effect of various mobile phase parameters on retention characteristics of "'In-DTPA and DTPA. The method was applied in stability study and routine quality control of "'In-DTPA radiopharmaceutical.