Many neuronal and behavioral processes are stereoselecrive, which means that they are dependent upon spatial (3-dimensional) features of biologically active molecules (Smith and Lehmann 1984). The usual way of studying stereoselectivity is to compare effects of enantiomers of racemic compounds (Port
HPLC analysis of cocaine diastereoisomers by chiral stationary phase
β Scribed by M. Chiarotti; N. Fucci
- Book ID
- 103903411
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 280 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0379-0738
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β¦ Synopsis
A complete chromatographic resolution of cocaine and pseudococaine by liquid chromatograpby is described. The chromatographic analysis was carried out using a chiral stationary phase (Supelcosil LC-urea) and acetonitrile as mobile phase. The proposed method can be employed in forensic toxicology to investigate whether or not illicit cocaine samples are from a synthetic source.
π SIMILAR VOLUMES
During the last decade, chiral stationary phases (CSPs) based on helical polymers, 1 proteins, 2 cellulose derivatives, 3 cyclodcxtrines, 4 rnacrocyclic antibiotics, 5 and low molecular weight optically active chiral