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hp, the Component of Log P Controlling Structure-activity Relationships Amongst Non-steroidal Anti-inflammatory Drugs

✍ Scribed by FRANCIS M. DEAN


Book ID
118110215
Publisher
Pharmaceutical Press
Year
1996
Tongue
English
Weight
574 KB
Volume
48
Category
Article
ISSN
2042-7158

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Specific binding of non-steroidal anti-i
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Type IIA secretory phospholipase A 2 (PLA 2 ) enzymes catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids to release fatty acids and lysophospholipids. In order to elucidate the role of PLA 2 in inflammatory disorders and to determine the mode of binding of non-steroidal antiinfla