How to investigate oxygen supply, uptake, and utilization simultaneously by interleaved NMR imaging and spectroscopy of the skeletal muscle
✍ Scribed by P. G Carlier; C. Brillault-Salvat; E. Giacomini; C. Wary; G. Bloch
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 258 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Human skeletal muscle perfusion, oxygenation, and high‐energy phosphate distribution were measured simultaneously by interleaved ^1^H and ^31^P NMR spectroscopy and ^1^H NMR imaging in vivo. From these parameters, arterial oxygen supply (DO~2~), muscle reoxygenation rate, mitochondrial ATP production, and O~2~ consumption (VO~2~) were deduced at the recovery phase of a short ischemic exercise bout. In addition, by using a reformulation of the mass conservation law, muscle maximum O~2~ extraction was calculated from these parameters. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.