HOW TO DIFFERENTIATE BETWEEN T-CELL-RICH B-CELL LYMPHOMA AND LYMPHOCYTE-PREDOMINANT HODGKIN'S DISEASE. EVIDENCE FOR THE VALUE OF MB1 AND 4KB5 IMMUNOSTAINING

✍ Scribed by SCHMIDT, U.; HERBST, J.; METZ, K. A.; LEDER, L.-D.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 843 KB
• Volume: 179
• Category: Article
• ISSN: 0022-3417
• DOI: 10.1002/(sici)1096-9896(199606)179:2<138::aid-path593>3.0.co;2-4

✦ Synopsis

Striking morphological similarities exist between T-cell-rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease (Hodgkin's paragranuloma), making the distinction between them extremely difficult. Immunohistochemistry proFides a means of overcoming this difficult!. lmmunostaining with UCHLl, L26, MB1, and 4KB5 was performed on five T-cell-rich B-cell lymphomas and 11 Hodgkin's paragranulomas (7/11 nodular, 4/11 diffuse). L26 stained the tumour cells not only of T-cell-rich B-cell lymphomas, but also of L + H Hodgkin's disease. In contrast, MB1 as well as 4KB5 identified all of the neoplastic cells in 315 T-cell-rich B-cell lymphomas, but did not react with the L + H cells in 811 I Hodgkin's paragranulomas. Some overlap of staining patterns became apparent in the remaining cases, with 2/5 T-cell-rich B-cell lymphomas showing the MBl'14KB5' phenotype in a tumour cell subset only. Similarlj, in 3/11 Hodgkin's paragranulomas, some MBlI4KBS-positive L + H cells occurred in addition to MBlI4KBS-negative L+H cells. These cases, nevertheless, could be distinguished from one another by the numbers of MBlI4KBS-positive background lymphocytes, which were scanty or absent in T-cell-rich B-cell lymphomas and more numerous in Hodgkin's paragranulomas.