How the projection domains of NF-L and α-internexin determine the conformations of NF-M and NF-H in neurofilaments
✍ Scribed by F. A. M. Leermakers; E. B. Zhulina
- Book ID
- 105946707
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 714 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1432-1017
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Expression of the genes that encode neurofilament proteins is considered to be confined normally to neurons. However, in demyelinating peripheral nerves Schwann cells upregulate the mRNA for the mediumsized neurofilament protein (NF-M), and cultured Schwann cells of the myelin-forming phenotype can
## Abstract This study focused mainly on changes in the microtubule cytoskeleton in a transgenic mouse where β‐galactosidase fused to a truncated neurofilament subunit led to a decrease in neurofilament triplet protein expression and a loss in neurofilament assembly and abolished transport into neu