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How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?

โœ Scribed by Felton, T.W.; Hope, W.W.; Roberts, J.A.


Book ID
122197589
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
745 KB
Volume
79
Category
Article
ISSN
0732-8893

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How severe is antibiotic pharmacokinetic
โœ Felton, T.W.; Hope, W.W.; Roberts, J.A. ๐Ÿ“‚ Article ๐Ÿ“… 2014 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 745 KB

The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients exhibit marked variability. This variability results from pathophysiological changes that occur in critically ill patients. Changes in volume of distribution, clearance, and tissue penetration all affect the dr