How severe is antibiotic pharmacokinetic
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Felton, T.W.; Hope, W.W.; Roberts, J.A.
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Article
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2014
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Elsevier Science
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English
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The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients exhibit marked variability. This variability results from pathophysiological changes that occur in critically ill patients. Changes in volume of distribution, clearance, and tissue penetration all affect the dr