Ir genes mapping to the H-2 region of the mouse MHC reflect the natural function of class I and II molecules as restriction elements for antigen-specific T-cell responses (Simpson and Gordon 1977, Benacerraf and Germain 1978, Berzofsky 1980, in press, Schwartz 1984). Cytotoxic T cells are generally
✦ LIBER ✦
How many class II immune response genes? A commentary on a reappraisal
✍ Scribed by Jan Klein
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 193 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0093-7711
No coin nor oath required. For personal study only.
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A human HLA-DQ beta-chain cDNA was used as a probe to identify and isolate a rat major histocompatibility antigen beta-chain gene from a genomic library constructed in the vector lambda Charon 28 using Wistar rat DNA (RT1u). The isolated exon of the rat gene (RT1.B beta 2) encoding a beta-chain seco