Early renal dysfunction following liver transplantation is associated with increased morbidity and mortality. To evaluate the impact of delayed initiation of calcineurin inhibitor on renal function, we conducted a retrospective study comparing 118 liver transplant recipients who received rabbit anti
How Long Should Initiation of Calcineurin Inhibitors Be Delayed to Protect Renal Function in Liver Transplantation?
β Scribed by L. Rafael-Valdivia; M.A. Mendoza; B. Martinez-Saldivar; A. Sanchez-Fueyo; M. Brunet; J.C. Garcia-Valdecasas; A. Rimola
- Book ID
- 116936878
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 91 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0041-1345
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Calcineurin inhibitors (CNIs) are the cornerstone of immunosuppression after liver transplantation. However, CNI treatment is frequently associated with chronic renal failure (CRF). The reduction or interruption of CNI may reduce renal failure. We prospectively studied 49 liver recipients treated wi
Chronic renal dysfunction is a frequent and severe complication in solid-organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and siro
The prevalence of renal insufficiency before and at 1, 12, and 60 months after liver transplantation (LTx; primary endpoint) and the changes in the glomerular filtration rate (GFR) at same time points according to the immunosuppressive regimen (coprimary endpoint) were investigated. The primary outc