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How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape

✍ Scribed by Mary, Sophie; Fehrentz, Jean‑Alain; Damian, Marjorie; Verdié, Pascal; Martinez, Jean; Marie, Jacky; Banères, Jean‑Louis

Book ID: 119971419
Publisher: Portland Press
Year: 2013
Tongue: English
Weight: 122 KB
Volume: 41
Category: Article
ISSN: 0300-5127
DOI: 10.1042/BST20120267

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## Abstract G protein‐coupled receptors (GPCRs) are seven‐transmembrane proteins (7‐TM) that transduce extracellular signals into cellular physiological responses through the activation of heterotrimeric guanine nucleotide binding proteins (αβγ subunits). Their general properties are remarkably wel