How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models
✍ Scribed by Bernd Porr; Lynsey McCabe; Paolo di Prodi; Christoph Kolodziejski; Florentin Wörgötter
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 509 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0893-6080
No coin nor oath required. For personal study only.
✦ Synopsis
It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters. Here, we investigate how plasticity is shaped by feedback inhibition in a cortical microcircuit. We use a differential Hebbian learning rule to model spike-timing-dependent plasticity and show analytically that the feedback inhibition shortens the time window for LTD during spike-timing-dependent plasticity but not for LTP. We then use a realistic GENESIS model to test two hypothesis about interneuron hypofunction and conclude that a reduction in GAD67 is the most likely candidate as the cause for hypofrontality as observed in Schizophrenia.