How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?
β Scribed by Mitsuko Okada; Hiroshi Nakanishi; Toshiaki Amamoto; Ryuji Urae; Susumu Ando; Kazuyoshi Yazawa; Michihiro Fujiwara
- Book ID
- 117386154
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 337 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0169-328X
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Rats were exposed to restraint coupled with 60, 1-sec, 1-mA, 60-Hz tail shocks. One hippocampus was immediately dissected for in vitro measurement of pairedpulse facilitation and LTP of the excitatory postsynaptic potential (EPSP) recording from the stratum radiatum of field CA1. There was no change
## Abstract Aging is associated with an impaired ability to maintain longβterm potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plast