How do yeast cells sense glucose?

✍ Scribed by Arthur L. Kruckeberg; Michael C. Walsh; Karel Van Dam

• Book ID: 101304777
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 79 KB
• Volume: 20
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/(sici)1521-1878(199812)20:12<972::aid-bies2>3.0.co;2-m

✦ Synopsis

A glucose-sensing mechanism has been described in Saccharomyces cerevisiae that regulates expression of glucose transporter genes. The sensor proteins Snf3 and Rgt2 are homologous to the transporters they regulate. Snf3 and Rgt2 are integral plasma membrane proteins with unique carboxy-terminal domains that are predicted to be localized in the cytoplasm. In a recent paper O ¨zcan and colleagues [O ¨zcan S, et al. EMBO J 1998;17:2556-2773 (Ref. 1)] present evidence that the cytoplasmic domains of Snf3 and Rgt2 are required to transmit a glucose signal. They provide additional evidence to support their earlier assertion [O ¨zcan S, et al.