How do synonymous mutations affect fitne
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Joanna L. Parmley; Laurence D. Hurst
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Article
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2007
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John Wiley and Sons
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English
β 76 KB
## Abstract While it has often been assumed that, in humans, synonymous mutations would have no effect on fitness, let alone cause disease, this position has been questioned over the last decade. There is now considerable evidence that such mutations can, for example, disrupt splicing and interfere