𝔖 Bobbio Scriptorium
✦   LIBER   ✦

How do mutant Nav1.1 sodium channels cause epilepsy?

✍ Scribed by David S. Ragsdale

Book ID
113506332
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
551 KB
Volume
58
Category
Article
ISSN
0165-0173

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

A rescuable folding defective Nav1.1 (SC
A rescuable folding defective Nav1.1 (SCN1A) sodium channel mutant causes GEFS+: Common mechanism in Nav1.1 related epilepsies?
✍ Raffaella Rusconi; Romina Combi; Sandrine CestΓ¨le; Daniele Grioni; Silvana Franc πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 822 KB

Mutations of voltage-gated Na + channels are the most common known cause of genetically determined epilepsy; Na v 1.1 (SCN1A) is the most frequent target. They can cause both mild and severe forms, also in patients harboring the same mutation. We have recently characterized in a family with extreme