How do cytotoxic lymphocytes kill their targets?

✍ Scribed by Sujan Shresta; Christine TN Pham; Dori A Thomas; Timothy A Graubert; Timothy J Ley

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 735 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80227-6

✦ Synopsis

CD8 + cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4 + T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.