✦ LIBER ✦
How chromatin prevents genomic rearrangements: Locus colocalization induced by transcription factor binding
✍ Scribed by Jérôme Déjardin
- Book ID
- 101705796
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 166 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
The loosening of chromatin structures gives rise to unrestricted access to DNA and thus transcription factors (TFs) can bind to their otherwise masked target sequences. Regions bound by the same set of TFs tend to be located in close proximity and this might increase the probability of activating illegitimate genomic rearrangements.