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Hotspots of homologous recombination in mammalian genomes

โœ Scribed by Michael Steinmetz; Yasushi Uematsu; Kirsten Fischer Lindahl

Book ID
113288468
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
405 KB
Volume
3
Category
Article
ISSN
0168-9525

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Genome instability has been associated with progression of transformed cells to high tumorigenicity. Although genome instability may result from a variety of factors, some studies suggest that DNA in the region of a chromosome rearrangement can subsequently have much higher rates of DNA deletions or