The left-handed polyproline II helix (PPII) is believed to be the preferred conformation for proline-rich regions of sequence in proteins. Such regions have been postulated to be protein-protein interaction domains. The formation of this structure is studied here using simple Monte Carlo computer si
✦ LIBER ✦
Host−Guest Study of Left-Handed Polyproline II Helix Formation †
✍ Scribed by Kelly, Melissa A.; Chellgren, Brian W.; Rucker, Adam L.; Troutman, Jerry M.; Fried, Michael G.; Miller, Anne-Frances; Creamer, Trevor P.
- Book ID
- 126797294
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 129 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0006-2960
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A newly designed host-guest approach is introduced as a experimental tool to explore the relationship between the sequence of peptides and their secondary structure. From the CD spectra of the host-guest peptides studied, a tentative scale for the a-helix potential in 2,Z.Z-trifluoroethanol of guest