## Abstract ## Background Gene transfer to salivary glands (SGs) can be accomplished in a minimally invasive manner, resulting in stable, long‐term secretion of the transgene product. Therefore, SGs provide a novel target site for several potentially useful clinical gene therapeutics applications.
✦ LIBER ✦
Host immune responses to salivary gland administration of recombinant adeno-associated virus serotype 2 vectors
✍ Scribed by MR Kok, A Voutetakis, S Yamano, J Wang, A Cotrim, H Katano, I Bossis…
- Book ID
- 120707078
- Publisher
- BioMed Central
- Year
- 2004
- Tongue
- English
- Weight
- 527 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar1120
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## Abstract ## Background Adeno‐associated virus serotype 2 (AAV2) vectors show considerable promise for ocular gene transfer. However, one potential barrier to efficacious long‐term therapy is the development of immune responses against the vector or transgene product. ## Methods We evaluated c