Host-guest interactions between β-cyclodextrin and piroxicam

✍ Scribed by A. Braibanti; E. Fisicaro; A. Ghiozzi; C. Compari; G. Bovis

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 410 KB
• Volume: 36
• Category: Article
• ISSN: 1381-5148
• DOI: 10.1016/s1381-5148(97)00100-4

✦ Synopsis

In order to obtain experimental evidence for the complexation between /?-cyclodextrin and piroxicam (Chydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-c~box~de-l,l-~oxide) and to investigate the thermodynamics of this interaction, a flow microcalorimetric study of this system has been undertaken. In fact, the mixing of #I-cyclodextrin and piroxicam in ratio 1 : 1 in given experimental conditions gives rise to a system showing better pharmacological properties than piroxicam alone. The results confirm the formation of a complex between B-cyclodextrin and piroxicam and allow the evaluation of the equilibrium constant for the process, assuming the formation of a 1 : 1 complex. It results in log K' = 3.54, where K' is the apparent formation constant at pH 9.00, in good agreement with literature data for similar compounds. The values of AH and AS are also reported.