Host focal adhesion protein domains that bind to the translocated intimin receptor (Tir) of enteropathogenicEscherichia coli (EPEC)

Interaction of the enteropathogenicEsche

Interaction of the enteropathogenicEscherichia coli protein, translocated intimin receptor (Tir), with focal adhesion proteins

✍ Freeman, Nancy L. ;Zurawski, Daniel V. ;Chowrashi, Prokash ;Ayoob, Joseph C. ;Hu 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 579 KB

When enteropathogenic Escherichia coli (EPEC) attach and infect host cells, they induce a cytoskeletal rearrangement and the formation of cytoplasmic columns of actin filaments called pedestals. The attached EPEC and pedestals move over the surface of the host cell in an actin-dependent reaction [Sa