Host brain environment affects differentiation of the grafted iPSC-derived dopaminergic neurons

Immune or inflammatory response by the h

Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell–derived neural precursor cells

✍ Makoto Ideguchi; Mizuya Shinoyama; Masanori Gomi; Hideki Hayashi; Nobuo Hashimot 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 531 KB

## Abstract Embryonic stem (ES) cells are a promising donor source for transplantation therapy, but several problems must be solved before they can be clinically useful. One of these is the host immune reaction to allogeneic grafts. In this article, we examine the effect of the host immune reaction