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Hormone—receptor interactions: [4-Carboranylalanine, 5-leucine] - enkephalin as a structural probe for the opiate receptor

✍ Scribed by Alex Eberle; Othmar Leukart; Peter Schiller; Jean-Luc Fauchère; Robert Schwyzer

Book ID
115907721
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
270 KB
Volume
82
Category
Article
ISSN
0014-5793

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📜 SIMILAR VOLUMES

The Synthesis of [4-Carboranylalanine, 5
The Synthesis of [4-Carboranylalanine, 5-Leucine]-Enkephalin (Including an Improved Preparation of t-Butoxycarbonyl-L-o-carboranylalnine, New Derivatives of L-Propargylglycine, and a Note on Melanotropic and Opiate Receptor Binding Characteristics)
✍ Jean-Luc Fauchère; Othmar Leukart; Alex Eberle; Robert Schwyzer 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 German ⚖ 646 KB

## Abstract The title compound, an analogue of [Leu^5^]‐enkephalin with L‐__o__‐carboranylalanine replacing L‐phenylalanine in position 4, was prepared by fragment condensation. The analogue has a 3‐fold higher affinity for rat brain opiate receptors in the [^3^H]naloxone competition assay than nat