Hormonally-Regulated Expression of Voltage-Operated Ca2+ Channels in Osteocytic (MLO-Y4) Cells
β Scribed by Y. Gu; M.R. Preston; J. Magnay; A.J. El Haj; S.J. Publicover
- Book ID
- 115587694
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 157 KB
- Volume
- 282
- Category
- Article
- ISSN
- 0006-291X
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SUMMARY: Freshly-dispersed bovine trachealis cells were used for recording by the patch clamp technique of whole-cell and unitary currents through \(\mathrm{Ca}^{2+}\)-channels. Whole-cell \(\mathrm{Ca}^{2+}\)-current \(\left(\mathrm{I}_{\mathrm{Ca}}\right.\) ) activated at \(-\mathbf{4 0 \mathrm {
Voltage-sensitive calcium channels (VSCCs) mediate signaling events in bone cells in response to mechanical loading. Osteoblasts predominantly express L-type VSCCs composed of the a 1 pore-forming subunit and several auxiliary subunits. Osteocytes, in contrast, express T-type VSCCs and a relatively