Hormonal treatment in pregnancy: A possible risk factor for neuroblastoma

✍ Scribed by Mandel, M. ;Toren, A. ;Rechavi, G. ;Dor, J. ;Ben-Bassat, I. ;Neumann, Y.

• Book ID: 102523610
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 291 KB
• Volume: 23
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950230212

✦ Synopsis

Abstract

In the last 4 years, 24 cases of neuroblastoma were treated in the Pediatric Hematology‐Oncology Unit at the Chaim Sheba Medical Center, 8 of whom were under 1 year of age. Four of them were the product of a pregnancy‐induced or preserved by gonadotropins, clomiphene citrate, or progestational hormones. These drugs are known to produce a higher than normal level of estradiol or progestrone in the early stages of pregnancy. Our observation led to the hypothesis that high levels of progestational hormones given during pregnancy are a risk factor for neuroblastoma in infancy. © 1994 Wiley‐Liss, Inc.