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Hormonal modulation of B cell development and repertoire selection

✍ Scribed by Christine M. Grimaldi; Latia Hill; Xiaonan Xu; Elena Peeva; Betty Diamond


Book ID
116755381
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
139 KB
Volume
42
Category
Article
ISSN
0161-5890

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Previous experiments with mouse chimeras demonstrated that cellular competition for antigen-speci"c survival signals plays a crucial role in the maintenance of the naive B cell repertoire. Transgenic (Tg) B cell populations in these chimeras have a shortened lifespan and poor competitive abilities a