## Abstract Hyperplasia of microglia is one characteristic of reactive gliosis, which is observed in various pathologic conditions in the central nervous system (CNS). To investigate the regulation mechanisms of microglial proliferation, the effect of granulocyte macrophage colony‐stimulating facto
✦ LIBER ✦
Hormonal Control and Putative Cell Cycle Dependency of AFP Production: Further Observations in vivo and in vitro
✍ Scribed by L. BÉLANGER; D. HAMEL; D. DUFOUR; A. GUILLOUZO; J. F. CHIU
- Book ID
- 110860329
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 582 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0300-9475
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An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metab