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Hopper flow electrostatics of tableting material I. Instrumentation and acetaminophen formulations

✍ Scribed by Gerald Gold; Blaze T. Palermo

Publisher: John Wiley and Sons
Year: 1965
Tongue: English
Weight: 330 KB
Volume: 54
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600540233

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✦ Synopsis

Instrumentation is described for measuring the sign and magnitude of static charges generated by particles flowing through a tablet hopper. Acetaminophen in the crystalline form had a higher negative hopper flow static charge than granulations prepared from the powder. Tablet excipients, such as diluents (dicalcium phosphate dihydrate, mannitol, and spray-dried lactose) and lubricants (magnesium stearate and talc), lowered the hopper flow static charge of acetaminophen. Particle size and water concentration were shown to influence the magnitude of the hopper %ow static charge.

TATIC ELECTRICITY in the strict sense means S electricity that is standing still. The term is

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Hopper flow electrostatics of tableting

Hopper flow electrostatics of tableting material II. Tablet lubricants

✍ Gerald Gold; Blaze T. Palermo 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB

In an evaluation of the antistatic properties of tablet lubricants, data were obtained to indicate that magnesium stearate, polyethylene glycol 4000, sodium lauryl sulfate, and talc have the ability to lower the accumulation of static charges resulting from the flow of material through a tablet ho p