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Hopeahainol A attenuates memory deficits by targeting β-amyloid in APP/PS1 transgenic mice

✍ Scribed by Zhu, Xiaolei; Ye, Lan; Ge, Huiming; Chen, Ling; Jiang, Nan; Qian, Lai; Li, Lingling; Liu, Rong; Ji, Shen; Zhang, Su; Jin, Jiali; Guan, Dening; Fang, Wei; Tan, Renxiang; Xu, Yun


Book ID
119825848
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
588 KB
Volume
12
Category
Article
ISSN
1474-9718

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## Abstract Memantine is a moderate‐affinity, uncompetitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist that stabilizes cognitive, functional, and behavioral decline in patients with moderate to severe Alzheimer's disease (AD). In AD, the extracellular deposition of fibrillogenic amyloid‐β pept