✦ LIBER ✦
Homoserine and threonine pools of borrelidin resistantSaccharomyces cerevisiaemutants with an altered aspartokinase
✍ Scribed by Michael Seibold; Karl Nill; Karl Poralla
- Book ID
- 104760676
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 345 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0302-8933
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✦ Synopsis
Borrelidin is a specific inhibitor of the threonyl-tRNA-synthethase. A class of dominant borrelidin resistant mutants (BOR1) of Saccharomyces cerevisiae was biochemically characterized. The mutants possess an altered aspartokinase which is insensitive to threonine inhibition. The threonine and homoserine pools in these mutants are 22 times larger than in the wild type. By feeding aspartate under a variety of conditions the homoserine pool is increased even 57 times whilst the threonine pool is reduced.