Homology modeling of milk enzymes using on-line resources: Insights to structure-function and evolutionary relationships

Homology modeling and deletion mutants o

Homology modeling and deletion mutants of human nicotinamide mononucleotide adenylyltransferase isozyme 2: New insights on structure and function relationship

✍ Lucia Brunetti; Michele Di Stefano; Silverio Ruggieri; Flavio Cimadamore; Giulio 📂 Article 📅 2010 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 624 KB

## Abstract Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of NAD by means of nucleophilic attack by 5′‐phosphoryl of NMN on the α‐phosphoryl group of ATP. Humans possess three NMNAT isozymes (NMNAT1, NMNAT2, and NMNAT3) that differ in size and sequence, gene expres