Homology modeling and flex-ligand docking studies on the guinea pig β2adrenoceptor: structural and experimental similarities/ differences with the human β2

Human serotonin 5-HT2C G protein-coupled

Human serotonin 5-HT2C G protein-coupled receptor homology model from the β2 adrenoceptor structure: Ligand docking and mutagenesis studies

✍ Tania Córdova-Sintjago; Nancy Villa; Clinton Canal; Raymond Booth 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 864 KB

## Abstract Activation of the serotonin (5‐hydroxytryptamine, 5‐HT) 5HT~2C~ G protein‐coupled receptor (GPCR) is proposed as novel pharmacotherapy for obesity and neuropsychiatric disorders. In contrast, activation of the 5‐HT~2A~ and 5‐HT~2B~ GPCRs is associated with untoward hallucinogenic and ca