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Homology among (βα)8 barrels: implications for the evolution of metabolic pathways

✍ Scribed by Richard R Copley; Peer Bork

Book ID: 115630584
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 924 KB
Volume: 303
Category: Article
ISSN: 0022-2836
DOI: 10.1006/jmbi.2000.4152

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## Abstract The question of parallel (α/β)~8~‐barrel fold evolution remains unclear, owing mainly to the lack of sequence homology throughout the amino acid sequences of (α/β)~8~‐barrel enzymes. The “classical” approaches used in the search for homologies among (α/β)~8~‐barrels (e.g., production of