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Homologous recombination in human iPS and ES cells for use in gene correction therapy

✍ Scribed by Manabu Nakayama


Book ID
113569080
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
127 KB
Volume
15
Category
Article
ISSN
1359-6446

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## Abstract ## Background Adeno‐associated virus (AAV) vectors have been shown to correct a variety of mutations in human cells by homologous recombination (HR) at high rates, which can overcome insertional mutagenesis and transgene silencing, two of the major hurdles in conventional gene addition