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Homologous desensitization of calcitonin gene-related peptide-induced relaxation in rat intramural coronary arteries

โœ Scribed by Majid Sheykhzade; Niels C Berg Nyborg

Book ID
113584414
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
476 KB
Volume
484
Category
Article
ISSN
0014-2999

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Homologous desensitization of calcitonin
Homologous desensitization of calcitonin gene-related peptide response in rat glomerular mesangial cells in culture
โœ Nambi Aiyar; Elayne Griffin; Christine Albrightson-Winslow; Giora Feuerstein; Po ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer ๐ŸŒ English โš– 487 KB

Addition of calcitonin gene-related peptide (CGRP) to rat glomerular mesangial cells in culture resulted in an increase in cyclic adenosine monophosphate (cAMP) accumulation in a concentration-dependent fashion with an EC50 of approximately 3 nM. Inclusion of CGRP8-37, a CGRP1 selective antagonist s